Indications And Clinical Uses: The topical management of allergic with inflammatory dermatoses responsive to corticosteroid therapy, such as psoriasis, atopic eczema, infantile eczema, nummular eczema, pruritus ani and vulvae, neurodermatitis (lichen simplex chronicus), intertrigo, contact dermatitis, seborrheic dermatitis, exfoliative dermatitis, solar dermatitis, stasis dermatitis and dyshidrosis. Refractory psoriasis may be care fore with Celestoderm-V especially in conjunction with the hydration technique of occlusive dressings.

The ointment formulations can be preferred for the treatment of dry, scaling and fissured lesions.

Celestoderm-V/2 includes a lower concentration (half strength) of betamethasone and is indicated for maintenance therapy after the acute phase has been brought under control, for less severe conditions and for extensive lesions involving large areas of the body surface.

Contra-Indications: Tuberculosis of skin, herpes simplex, varicella, vaccinia, superficial fungus or mushroom infections. Patients with a times past of sensitivity reactions to any of its components. Application in or near the eyes should be avoided.

Precautions: Corticosteroids are well-known to be absorbed percutaneously in patients under prolonged treatment, with extensive body surface treatment or particularly in those using the occlusive dressing technique on large areas of the body. In such cases, it is advised that kidney function studies such as BUN be carried out prior to treatment and regularly throughout the course of the treatment.

Pregnancy and Lactation: Because safety of topical corticosteroid use in pregnant women has not been established, drugs of this class should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Drugs of this class be supposed to not be used extensively in large amounts or for prolonged periods of time in pregnant patients. Since it is not recognized whether topical administration of corticosteroids can result in sufficient systemic absorption to produce detectable quantities in breast milk, a decision should be made to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Children: Any of the side results that have been reported following systemic use of corticosteroids, including adrenal suppression, may also occur with topical corticosteroids, especially in infants and children.

Systemic absorption of topical corticosteroids will be more if extensive body surface areas are treated or if the occlusive technique is used. Appropriate precautions should be taken under these conditions or when long-term use is anticipated, particularly in infants and children. Pediatric patients may demonstrate better susceptibility to topical corticosteroid-induced HPA axis suppression and Cushing’s syndrome than grown-up patients because of a larger skin surface area to body weight ratio. HPA axis suppression, Cushing’s syndrome, linear growth retardation, delayed weight gain, and intracranial hypertension have been reported in children receiving topical corticosteroids. Manifestations of adrenal repression in children include low plasma cortisol levels and absence of response to ACTH stimulation. Manifestations of intracranial hypertension contain a bulging fontanelle, headaches and bilateral papilledema. Use of topical corticosteroids in children be supposed to be limited to the least amount compatible with an effective therapeutic regimen.

When continuing topical treatment under occlusive dressings is necessary, small dosages, rotation of sites and intermittent therapy should be considered.

Patients be supposed to be advised to inform subsequent physicians of the prior use of corticosteroids.

In the presence of infection, Celestoderm-V preparations be supposed to be superseded by suitable antibacterial agents until the infection has cleared.

Adverse Reactions: With use of topical corticosteroids, limited reactions have been reported, namely, burning sensation, itching, irritation, dryness, hypertrichosis, acneiform eruptions, and hypopigmentation. Striae, secondary disease, atrophy, miliaria, folliculitis, and pyodermas also occur but more frequently with use of occlusive dressings. Contact sensitivity to a exacting dressing material or adhesive may occur occasionally.

Symptoms And Treatment Of Overdose: Symptoms: Excessive or prolonged apply of topical corticosteroids can suppress pituitary-adrenal function, resulting in secondary adrenal insufficiency, and produce manifestations of hypercorticism, including Cushing’s disease. tag_Treatment

Treatment: Appropriate symptomatic treatment is indicated. Acute hypercorticoid symptoms are usually reversible. Treat electrolyte imbalance, if necessary. In case of chronic toxicity, slow withdrawal of corticosteroids is advice.

Dosage And Administration: Apply a small total on the affected skin 2 or 3 times daily. Refractory lesions of psoriasis and added deep seated dermatoses such as lichen simplex chronicus, hypertrophic lichen planus, atopic dermatitis, chronic eczematous and lichenified hand eruptions, and recalcitrant pustular eruptions on the palms and soles will respond better to topical corticosteroids when used with the hydration technique of occlusive dressing. This technique lessens evaporation from the skin by means of a closed impermeable dressing over the lesion.

Occlusive Dressing Technique: 1. Apply a thick layer of the cream or ointment over the full surface of the lesion under a light gauze dressing and then cover it with a pliable, transparent, impermeable, plastic material well beyond the treated area.

2. Seal the edges to the usual skin by adhesive tape or other means.

3. Depart the dressing in place 1 to 3 days and repeat the procedure 3 or 4 times as needed. With this technique of treatment, marked improvement often is seen in a few days. Irregularly, a miliary eruption or folliculitis develops in the skin under the occlusive dressing requiring removal of the plastic covering.

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